Seems like one of the main features of this page is interesting frame breaks. In mocking up some sample pages I tried to choose some art that could lead to interesting versions of this.
01: Akali
With this hero I added a glint to the knife breaking out of the frame on the left. This makes it pop just a touch more.
On the right we have some steam floating out of the frame. It is not quite opaque, and the edge of the frame creates a nice “laser in fog” effect.
02: Cassiopeia
As I have yet to see it, I am not certain if the system allows to break out of the bottom of the frame. If so, Cassiopeia is an interesting hero to do so with. Her bottom-heavy snake body makes for an interesting graphic effect.